Respiratory Dysfunction and Abnormal Hypoxic Ventilatory Response in Mild to Moderate Parkinson's Disease.

ABSTRACT:

Background

Respiratory dysfunction is an important contributor to morbidity and mortality in advanced Parkinson's disease (PD), but it is unclear what parameters are sensitive to diagnose and monitor respiratory dysfunction across disease phases.

Objectives

We aimed to characterize respiratory dysfunction in mild to moderate PD.

Methods

In 20 individuals without cardiopulmonary comorbidity, pulmonary and inspiratory muscle function testing were performed ON-medication. Subsequently, the acute ventilatory response to hypoxia (HVR) was assessed by gradually decreasing F_IO₂ from 0.209 (room air) to 0.127, which was compared to eight age- and sex-matched healthy controls under arterial blood gas monitoring. Lastly, on different days, the same 20 indi

SUBMITTER: Janssen Daalen JM 

PROVIDER: S-EPMC11647984 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature