Quantitative Tractography-Based Evaluations in Essential Tremor Patients after MRgFUS Thalamotomy.

ABSTRACT:

Background

Magnetic resonance-guided focused ultrasound (MRgFUS) targeting the thalamic ventral intermediate nucleus (VIM) is an innovative treatment for drug-refractory essential tremor (ET). The relationship between lesion characteristics, dentate-rubro-thalamic-tract (DRTT) involvement and clinical benefit remains unclear.

Objectives

To investigate whether clinical outcome is related to lesion volume and/or its overlap with the DRTT. To compare the reliability of probabilistic versus deterministic tractography in reconstructing the DRTT and improving VIM targeting.

Methods

Forty ET patients who underwent MRgFUS thalamotomy between 2019 and 2022 were retrospectively analyzed. Clinical outcomes and adverse effects were recorded at 1/6/12 months after the procedure. T

SUBMITTER: Ghielmetti F 

PROVIDER: S-EPMC11648004 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature