Obesity, Metabolic Health, and Diabetic Complications in People With Type 1 Diabetes.

ABSTRACT:

Aim

The concept of metabolically healthy obesity (MHO) has not been studied in type 1 diabetes (T1D). By analysing datasets from the DCCT/EDIC study, we compared the development of diabetic complications by obesity and metabolic health over 30 years of follow up.

Materials and methods

Insulin resistance was calculated by estimated glucose disposal rate (eGDR). The participants (n = 1127) were then divided into four groups based on time-weighted mean body mass index and mean eGDR: metabolically healthy non-obesity (MHN, n = 874), metabolically unhealthy non-obesity (MUN, n = 66), MHO (n = 146) and metabolically unhealthy obesity (MUO, n = 41). Diabetic complications and cardiovascular events were compared across the four groups.

Results

MUO and MUN groups had significa

SUBMITTER: Mao Y 

PROVIDER: S-EPMC11648318 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature