Experimental verification of halomethyl carbinol synthesis from carbonyl compounds using a TiCl₄-Mg bimetallic complex promoter.

ABSTRACT: A critical evaluation of the feasibility of a previously published method for synthesising halomethyl carbinols from carbonyl compounds and CH₂Br₂ or CH₂Cl₂ using a bimetallic TiCl₄-Mg complex is presented. The synthesis of compounds lacking the -CH₂- group in their structure was achieved by following the procedures proposed in the reference literature or by introducing modifications to selected process parameters. These compounds were not identified as expected β-halohydrins but as products of reductive dimerisation or subsequent pinacolic rearrangement of carbonyl substrates. This paper proposes a formation mechanism of vicinal 1,2-diols in the presence of a TiCl₄-Mg system, supported by experimental data and th

SUBMITTER: Michalak O 

PROVIDER: S-EPMC11648366 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature