Comparison of antifungal drugs in the treatment of invasive pulmonary aspergillosis: a systematic review and network meta-analysis.

ABSTRACT:

Background

Voriconazole, isavuconazole, and amphotericin (AmB) formulations are currently recommended to treat invasive pulmonary aspergillosis (IPA). We aimed to estimate the efficacy of different antifungal drugs in the initial treatment of IPA.

Methods

We included all available randomized controlled trials (RCTs) evaluating first-line treatments for IPA by searching PubMed, Medline, EMBASE, the Cochrane Library, and the ClinicalTrials.gov database. We performed a network meta-analysis to compare the relative efficacy of different drugs in treating IPA. The primary outcomes were the overall response and all-cause mortality (ACM).

Results

Eight studies were identified that compared different drugs including voriconazole, isavuconazole, posaconazole, anidulafungin, li

SUBMITTER: Cheng J 

PROVIDER: S-EPMC11648418 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature