Identification of important extracellular vesicle RNA molecules related to sperm motility and prostate cancer.

ABSTRACT:

Aim

Many male diseases are associated with sperm quality, such as prostate cancer (PCa), oligospermia, and asthenospermia. Seminal plasma extracellular vesicles (SPEVs) play important roles in sperm function. In this study, we explored the specific RNA molecules in SPEVs that play an important role in sperm motility and found promising biomarkers of PCa in SPEVs.

Methods

Pigs have become an ideal model for human biomedical research. In this study, the whole transcriptome profiles of SPEVs of boars with high or low sperm motility were studied for the first time. Important long non-coding RNAs, microRNAs, and genes were identified through differentially expressed analysis and weighted correlation network analysis (WGCNA). In addition, we established a diagnosis model of PCa by

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11648515 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature