A multi-scale brain map derived from whole-brain volumetric reconstructions.

ABSTRACT: Animal nervous system organization is crucial for all body functions and its disruption can lead to severe cognitive and behavioural impairment¹. This organization relies on features across scales-from the localization of synapses at the nanoscale, through neurons, which possess intricate neuronal morphologies that underpin circuit organization, to stereotyped connections between different regions of the brain². The sheer complexity of this organ means that the feat of reconstructing and modelling the structure of a complete nervous system that is integrated across all of these scales has yet to be achieved. Here we present a complete structure-function model of the main neuropil in the nematode Caenorhabditis elegans-the nerve ring-which we derive by integrating the

SUBMITTER: Brittin CA 

PROVIDER: S-EPMC11648602 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature