TRPC6 is a mechanosensitive channel essential for ultrasound neuromodulation in the mammalian brain.

ABSTRACT: Ultrasound neuromodulation has become an innovative technology that enables noninvasive intervention in mammalian brain circuits with high spatiotemporal precision. Despite the expanding utility of ultrasound neuromodulation in the neuroscience research field and clinical applications, the molecular and cellular mechanisms by which ultrasound impacts neural activity in the brain are still largely unknown. Here, we report that transient receptor potential canonical 6 (TRPC6), a mechanosensitive nonselective cation channel, is essential for ultrasound neuromodulation of mammalian neurons in vitro and in vivo. We first demonstrated that ultrasound irradiation elicited rapid and robust Ca²⁺ transients mediated via extracellular Ca²⁺ influx in cultured mouse cortical and h

SUBMITTER: Matsushita Y 

PROVIDER: S-EPMC11648612 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature