An integrated picture of the structural pathways controlling the heart performance.

ABSTRACT: The regulation of heart function is attributed to a dual filament mechanism: i) the Ca²⁺-dependent structural changes in the regulatory proteins of the thin, actin-containing filament making actin available for myosin motor attachment, and ii) the release of motors from their folded (OFF) state on the surface of the thick filament allowing them to attach and pull the actin filament. Thick filament mechanosensing is thought to control the number of motors switching ON in relation to the systolic performance, but its molecular basis is still controversial. Here, we use high spatial resolution X-ray diffraction data from electrically paced rat trabeculae and papillary muscles to provide a molecular explanation of the modulation of heart performance that calls for a revision of the

SUBMITTER: Morotti I 

PROVIDER: S-EPMC11648670 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature