The bile acid metabolome in umbilical cord blood and meconium of healthy newborns: distinct characteristics and implications.

ABSTRACT:

Objective

To characterize the bile acid metabolomic profiles of umbilical cord blood and meconium in healthy newborns.

Methods

Fifteen healthy newborns, which born in the Obstetrics Department of the Affiliated Hospital of Southwest Medical University between July 1 and August 31, 2023, were selected as study subjects. Umbilical cord blood and meconium samples were collected, and bile acid metabolomics were analyzed using ultra-high performance liquid chromatography-tandem mass spectrometry.

Results

The ratio of primary to secondary bile acids in cord blood was significantly higher than in meconium [2.64 (2.49, 5.70) vs. 0.99 (0.37, 1.58), Z = -3.80, P < 0.05]. The ratio of unconjugated to conjugated bile acids was notably higher in cord blood than in me

SUBMITTER: Lu C 

PROVIDER: S-EPMC11648689 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature