The influence of severity of hemophilia on bone mineral density and fracture risk.

ABSTRACT:

Background

Evidence states that persons with hemophilia are frequently affected by low bone mineral density (BMD). Data assessing the relationship between severity of hemophilia and occurrence of osteoporosis are lacking.

Objectives

This prospective cohort study aimed to assess the impact of hemophilia severity on BMD and to investigate trabecular bone score (TBS) and fracture risk (FRAX).

Methods

This prospective cohort study evaluated the BMD, TBS, and FRAX in 255 persons with hemophilia using dual x-ray absorptiometry. The International Society for Clinical Densitometry guidelines were used for classification: osteoporosis (T-score <-2.5), osteopenia (T-score <-1.0), normal (T-score >-1.0). Patients younger than 50 years of age with a Z-score of <-2.0 were consider

SUBMITTER: Ransmann P 

PROVIDER: S-EPMC11648757 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature