Goose astrovirus induces apoptosis and endoplasmic reticulum stress in gosling hepatocytes.

ABSTRACT: The ongoing Goose astrovirus (GoAstV) epidemic, which primarily infects goslings causing severe liver damage, has inflicted considerable damage on the poultry industry. Endoplasmic reticulum stress (ERS) is a significant modulator of several viral infections, while severe ERS may result in apoptosis. This study examined the roles and possible mechanisms of ERS and apoptosis in GoAstV-induced liver injury in goslings. Two hundred Xingguo gray geese were chosen and randomly separated into two groups (Con and Dis). The Dis group received a subcutaneous injection of GoAstV genotype 2 (GoAstV-2) JX01 (2 × 10⁶ TCID₅₀/0.2 mL), whereas the Con group received a subcutaneous injection of 0.2 mL physiological saline, both at 1 day of life. Subsequent analyses demonstrate that th

SUBMITTER: Lu Z 

PROVIDER: S-EPMC11648764 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature