Dependence of clot structure and fibrinolysis on apixaban and clotting activator.

ABSTRACT:

Background

Anticoagulants prevent the formation of potentially fatal blood clots. Apixaban is a direct oral anticoagulant that inhibits factor (F)Xa, thereby impeding the conversion of prothrombin into thrombin and the formation of blood clots. Blood clots are held together by fibrin networks that must be broken down (fibrinolysis) to restore blood flow. Fibrinolysis is initiated when tissue plasminogen activator (tPA) converts plasminogen to plasmin, which binds to and degrades a fibrin fiber. The effects of apixaban on clot structure and lysis have been incompletely studied.

Objectives

We aimed to study apixaban effects on clot structure, kinetics, and fibrinolysis using thrombin (low or high concentration) or tissue factor (TF) to activate clot formation.

Methods

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SUBMITTER: Risman RA 

PROVIDER: S-EPMC11648767 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature