ALDH1L2 drives HCC progression through TAM polarization.

ABSTRACT:

Background & aims

Dysregulation of one-carbon metabolism is considered an early hallmark of mitochondrial dysfunction and cancer metabolism. ALDH1L2 belongs to the aldehyde dehydrogenase family and plays an important role in tumor progression. However, little is known about the precise role and underlying mechanisms of ALDH1L2 in hepatocellular carcinoma (HCC).

Methods

Immunohistochemistry, western blotting, and immunofluorescence staining were used to evaluate ALDH1L2 expression in HCC samples (n = 90) and cell lines (n = 9). A series of in vitro and in vivo assays were performed to explore the role and molecular mechanism of ALDH1L2 in HCC progression.

Results

ALDH1L2 upregulation is associated with poor prognosis in HCC (hazard ratio 1.923; 95% confid

SUBMITTER: Li J 

PROVIDER: S-EPMC11648791 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature