An In Vivo Mouse Model for Chronic Inflammation-Induced Immune Suppression: A "Factory" for Myeloid-Derived Suppressor Cells (MDSCs).

ABSTRACT: Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells known to play a role in perpetuating a wide range of pathologies, such as chronic infections, autoimmune diseases, and cancer. MDSCs were first identified in mice by the markers CD11b⁺ Gr1⁺ , and later, based on their morphology, they were classified into two subsets: polymorphonuclear MDSCs, identified by the markers CD11b⁺ Ly6G⁺ Ly6C^Low , and monocytic MDSCs, detected as being CD11b⁺ Ly6G^- Ly6C^Hi . MDSCs are studied as immunosuppressive cells in various diseases characterized by chronic inflammation and are associated with disease causes/triggers such as pathogens, autoantigens, and cancer. Therefor

SUBMITTER: Ben-Meir K 

PROVIDER: S-EPMC11648823 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature