Widespread neuroanatomical integration and distinct electrophysiological properties of glioma-innervating neurons.

ABSTRACT: Gliomas are the most common malignant primary brain tumor and are often associated with severe neurological deficits and mortality. Unlike many cancers, gliomas rarely metastasize outside the brain, indicating a possible dependency on unique features of brain microenvironment. Synapses between neurons and glioma cells exist, suggesting that glioma cells rely on neuronal inputs and synaptic signaling for proliferation. Yet, the locations and properties of neurons that innervate gliomas have remained elusive. In this study, we utilized transsynaptic tracing with an EnvA-pseudotyped, glycoprotein-deleted rabies virus to specifically infect TVA and glycoprotein-expressing human glioblastoma cells in an orthotopic xenograft mouse model, allowing us to identify the neurons that form synapses ont

SUBMITTER: Hsieh AL 

PROVIDER: S-EPMC11648874 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature