Alternative splicing of Clock transcript mediates the response of circadian clocks to temperature changes.

ABSTRACT: Circadian clocks respond to temperature changes over the calendar year, allowing organisms to adjust their daily biological rhythms to optimize health and fitness. In Drosophila, seasonal adaptations are regulated by temperature-sensitive alternative splicing (AS) of period (per) and timeless (tim) genes that encode key transcriptional repressors of clock gene expression. Although Clock (Clk) gene encodes the critical activator of circadian gene expression, AS of its transcripts and its potential role in temperature regulation of clock function have not been explored. Here, we observed that Clk transcripts undergo temperature-sensitive AS. Specifically, cold temperature leads to the production of an alternative Clk transcript,

SUBMITTER: Cai YD 

PROVIDER: S-EPMC11648895 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature