Better kidney allograft survival despite higher-risk donor and recipient characteristics between 1995 and 2014.

ABSTRACT:

Background and hypothesis

Advances in organ procurement, surgical techniques, immunosuppression regimens, and prophylactic antibiotic therapies have dramatically improved kidney transplant graft failure. It is unclear how these interventions have affected longer-term graft failure. It is hypothesized that graft failure has improved over the last 20 years.

Methods

Data on all first kidney transplants from 1995 to 2014 were extracted from the Australia and New Zealand Dialysis and Transplant Registry with follow-up as of 31 December 2021. Primary exposure was transplant era, classified into 5-year intervals. Primary outcome was all-cause 5-year graft failure. Secondary outcomes included all-cause 10-year graft failure and cause-specific graft failure. Kaplan-Meier curves and m

SUBMITTER: Ng MSY 

PROVIDER: S-EPMC11648957 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature