Hypusination in intestinal epithelial cells protects mice from infectious colitis.

ABSTRACT: Enteropathogenic Escherichia coli (EPEC) is a bacterium that causes attaching/effacing (A/E) lesions and serious diarrheal disease, a major health issue in developing countries. EPEC pathogenicity results from the effect of virulence factors and dysregulation of host responses. Polyamines, including spermidine, play a major role in intestinal homeostasis. Spermidine is the substrate for deoxyhypusine synthase (DHPS), which catalyzes the conjugation of the amino acid hypusine to eukaryotic translation initiation factor 5A (EIF5A); hypusinated EIF5A (EIF5A^Hyp) binds specific mRNAs and initiates translation. Our aim was to determine the role of hypusination during infection with A/E pathogens. We found that DHPS and EIF5A^Hyp levels are induced in i) a colonic epit

SUBMITTER: Gobert AP 

PROVIDER: S-EPMC11649231 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature