Exploring the Impact of Sarcopenia on Mortality in Breast Cancer Patients: A Comprehensive Systematic Review and Meta-Analysis.

ABSTRACT:

Background

This study assesses the frequency of sarcopenia in patients with breast cancer (BC) and its association with mortality rates.

Methods

An all-encompassing search across (PubMed, Scopus, Web of Science, and CINAHL) was done, to identify studies, published until August 2023, that report data on sarcopenia and mortality in BC patients. A meta-analysis was then done using a random-effects model.

Results

Out of 989 initially identified potential studies, 19 met inclusion criteria. Analysis of 15 studies showed a rate of sarcopenia of 38% (95% CI: 29-48%), with moderate heterogeneity (I ² = 25.8%). Sarcopenia was linked to increased mortality risk in BC patients across 16 studies (HR: 1.77, CI: 1.35-2.32, p = <0.001) with both shorter and

SUBMITTER: Dai Y 

PROVIDER: S-EPMC11649298 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature