Single-cell transcriptome analysis reveals status changes of immune cells in chronic kidney disease.

ABSTRACT:

Background and aims

The immune system plays a crucial role in the development of kidney diseases. Chronic kidney disease (CKD) can lead to various complications, potentially affecting multiple systems throughout the body. Currently, the description of the immune system in human CKD is not comprehensive enough. Constructing a CKD kidney atlas using single-cell RNA sequencing (scRNA-seq) can provide deeper insights into the composition and functional changes of immune cells in CKD, facilitating the discovery of new therapeutic targets.

Methods

We processed and integrated scRNA-seq datasets from healthy and CKD kidneys from three independent cohorts using the same approach (including 42 normal samples and 23 chronic kidney disease samples). Subsequently, we conducted gene enric

SUBMITTER: Fan X 

PROVIDER: S-EPMC11649435 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature