Recurrence and treatment trends of pancreatic neuroendocrine tumors.

ABSTRACT:

Introduction

The management of recurrent pancreatic neuroendocrine tumors has changed with improvements in both systemic and locoregional therapies. This study aims to describe the patterns of recurrence and respective treatments and evaluate the changes in multimodality treatment.

Methods

This is a single-institution retrospective study of patients diagnosed with a pancreatic neuroendocrine tumor from 2004 to 2022. The primary outcome was time to recurrence. Secondary outcomes included overall survival and therapeutic modality. Time to event probabilities were calculated using the Kaplan-Meier method; probabilities were compared using log-rank tests. Cox proportional hazards multivariable modeling with competing risks yielded subdistribution hazard ratios.

Results

Of

SUBMITTER: Bader A 

PROVIDER: S-EPMC11649455 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature