Polygenic prediction of major depressive disorder and related traits in African ancestries UK Biobank participants.

ABSTRACT: Genome-Wide Association Studies (GWAS) over-represent European ancestries, neglecting all other ancestry groups and low-income nations. Consequently, polygenic risk scores (PRS) more accurately predict complex traits in Europeans than African Ancestries groups. Very few studies have looked at the transferability of European-derived PRS for behavioural and mental health phenotypes to Africans. We assessed the comparative accuracy of depression PRS trained on European and African Ancestries GWAS studies to predict major depressive disorder (MDD) and related traits in African ancestry participants from the UK Biobank. UK Biobank participants were selected based on Principal component analysis clustering with an African genetic similarity reference population, MDD was assessed with the Composi

SUBMITTER: Kanjira SC 

PROVIDER: S-EPMC11649553 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature