Aberrant associations between neuronal resting-state fluctuations and working memory-induced activity in major depressive disorder.

ABSTRACT: Previous investigations have revealed performance deficits and altered neural processes during working-memory (WM) tasks in major depressive disorder (MDD). While most of these studies used task-based functional magnetic resonance imaging (fMRI), there is an increasing interest in resting-state fMRI to characterize aberrant network dynamics involved in this and other MDD-associated symptoms. It has been proposed that activity during the resting-state represents characteristics of brain-wide functional organization, which could be highly relevant for the efficient execution of cognitive tasks. However, the dynamics linking resting-state properties and task-evoked activity remain poorly understood. Therefore, the present study investigated the association between spontaneous activity as indi

SUBMITTER: Hempel M 

PROVIDER: S-EPMC11649556 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature