CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ.

ABSTRACT:

Introduction

Head and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3ζ) is central to various signalling pathways and is pivotal in tumour progression.

Methods

Cancerous and corresponding non-cancerous tissue samples were collected from five patients diagnosed with HNSCC. circRNA and mRNA expression profiles were analyzed using high-throughput sequencing techniques. Potential circRNA-microRNA (miRNA)-mRNA interactions were predicted using bioinformatics tools.

Results

The study found that CircRNA_036186 regulates the expression of 14-3-3ζ in HNSCC through miR-193b-5p.

Discussion

These findings suggest that C

SUBMITTER: Tang J 

PROVIDER: S-EPMC11649647 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature