Associations of posttraumatic stress disorder symptoms with amyloid burden in cognitively normal older adults.

ABSTRACT:

Background

Posttraumatic stress disorder (PTSD) is associated with the development of dementia. However, the link between PTSD and preclinical Alzheimer's disease pathology (amyloid β [Aβ]) remains controversial. Moreover, the correlation between the severity of PTSD with Aβ levels remains unknown.

Methods

This cross-sectional study sought to investigate the associations of PTSD symptoms with global and regional brain Aβ burden. To this end, data were obtained from participants in the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Study. In addition, we explored the association between the severity of PTSD symptoms and Aβ levels.

Results

A total of 4,228 participants aged 65 to 85 years were included in the final analysis. The results showed th

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11649661 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature