Transcriptionally distinct B cell profiles in systemic immune tissues and peritoneal cavity of Atlantic salmon (<i>Salmo salar</i>) infected with salmonid alphavirus subtype 3.

ABSTRACT: Teleost B cells producing neutralizing antibodies contribute to protection against salmonid alphavirus (SAV) infection, the etiological agent of pancreas disease, thereby reducing mortality and disease severity. Our previous studies show differences in B cell responses between the systemic immune tissues (head kidney (HK) and spleen) and the peritoneal cavity (PerC) after intraperitoneal SAV3 infection in Atlantic salmon (Salmo salar) where the response in PerC dominates at the late time points. By employing the same infection model, we aimed to further characterize these B cells. Immunophenotyping of teleost B cells is challenging due to limited availability of markers; however, RNA-seq opens an opportunity to explore differences in transcriptomic responses of these cells. Our anal

SUBMITTER: Jenberie S 

PROVIDER: S-EPMC11649679 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature