Protective effect of interferon type I on barrier function of human airway epithelium during rhinovirus infections in vitro.

ABSTRACT: The airway epithelium provides a crucial barrier against infection with respiratory pathogens. This barrier can be impaired following viral infection, paving the way for bacterial superinfections. Type I interferons (IFNs) are important antiviral mediators, and inhaled formulations of these glycoproteins are considered a potential approach for the treatment of respiratory viral infections. To investigate if type I IFNs can also protect against virus-induced epithelial barrier dysfunction, differentiated primary bronchial epithelial cells were pre-treated with IFN-β1a and subsequently infected with human rhinovirus (HRV) for 24 to 72h. Moreover, to functionally assess the effects of IFN-β1a pre-treatment on barrier integrity, we conducted co-infection experiments, in which cells were initia

SUBMITTER: Boland H 

PROVIDER: S-EPMC11649702 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature