Hydroxychloroquine blood concentrations and effects in Chinese patients with IgA nephropathy.

ABSTRACT:

Background

Hydroxychloroquine (HCQ) is recommended for Chinese patients with immunoglobulin A nephropathy (IgAN). However, the relationship between HCQ blood concentration and the therapeutic effect for IgAN has not yet been defined. This study investigates the optimal and efficacious range of HCQ blood concentrations in Chinese patients with IgAN.

Methods

Seventy-three patients with biopsy-proven IgAN who were at risk of progression were included in this study. Thirty-eight patients with IgAN were treated with HCQ plus an optimized renin-angiotensin-aldosterone system inhibitor (RAASi), and thirty-five patients received only RAASi. Blood HCQ concentration and 24-h proteinuria were examined at three and six months after treatment.

Results

The baseline proteinuria leve

SUBMITTER: Yang T 

PROVIDER: S-EPMC11649793 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature