Infertility following trisomic pregnancies: A nationwide cohort study.

ABSTRACT:

Objective

To study whether gynecologic or reproductive disorders show association with trisomic conceptions.

Methods

This nationwide cohort study utilized the Registry of Congenital Malformations to identify women who had a trisomic pregnancy (n = 5784), either with trisomy 13 (T13; n = 351), trisomy 18 (T18; n = 1065) or trisomy 21 (T21; n = 4369) from 1987 to 2018. We used the Finnish Maternity cohort to match the cases to population controls (n = 34 422) on the age, residence, and timing of pregnancy. These data were cross-linked to the ICD-10 diagnoses of the national Care Registry for Health Care data on specialized health care in Finland during 1996 to 2019. Both inflammatory (ICD-10 diagnoses: N70-N77) and noninflammatory disorders of the genital tract (N80-N98) were

SUBMITTER: Wedenoja S 

PROVIDER: S-EPMC11649879 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature