Reduced brain network segregation in alcohol use disorder: Associations with neurocognition.

ABSTRACT: The human brain consists of functionally segregated networks, characterized by strong connections among regions belonging to the same network and weak connections between those of different networks. Alcohol use disorder (AUD) is associated with premature brain aging and neurocognitive impairments. Given the link between decreased brain network segregation and age-related cognitive decline, we hypothesized lower brain segregation in patients with AUD than healthy controls (HCs). Thirty AUD patients (9 females, 21 males) and 61 HCs (35 females, 26 males) underwent resting-state functional MRI (rs-fMRI), whose data were processed to assess segregation within the brain sensorimotor and association networks. We found that, compared to HCs, AUD patients had significantly lower segregation in bo

SUBMITTER: Wang X 

PROVIDER: S-EPMC11649955 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature