Mineralocorticoid receptor activates postnatal adiposity in zebrafish lacking proopiomelanocortin.

ABSTRACT: The proopiomelanocortin (Pomc)-derived peptides, including adrenocorticotropic hormone and α-melanocyte stimulating hormone (α-Msh), play both a central and a peripheral role in modulating the stress response. The central role is predominantly associated with nutrient homeostasis, while peripherally they play an important role in the synthesis of glucocorticoids (GCs) in response to stress. Pomc mutations are a major risk factor in the development of early-onset childhood obesity in humans. This is attributed primarily to their central effects on melanocortin receptor dysfunction leading to hyperphagia and reduced energy expenditure, while the peripheral mechanism contributing to obesity has largely been unexplored. Here, we tested the hypothesis that Pomc mutation-mediated adrenal insuffi

SUBMITTER: Rajeswari JJ 

PROVIDER: S-EPMC11649959 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature