Predictive value of residual active histologic lesions on renal flare in lupus nephritis patients with clinical remission.

ABSTRACT:

Background

Renal flare in lupus nephritis (LN) is a crucial contributing factor to poor kidney outcomes. This study aimed at evaluating the predictive value of residual active histologic lesions on renal flare in proliferative LN patients with clinical remission.

Methods

We retrospectively enrolled LN patients with class III/IV ± V (biopsy 1) who had undergone a protocol repeat biopsy (biopsy 2) at 7.3 (IQR: 6.5, 8.4) months after induction therapy with clinical remission and experienced renal flare within 3 years or had been followed up for at least 3 years without renal flare after biopsy 2 with maintenance therapy from two kidney units in China.

Results

A total of 114 eligible patients were included, 28 (24.6%) of whom developed a renal flare. Activity index (AI) a

SUBMITTER: Hou J 

PROVIDER: S-EPMC11650015 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature