The effect of polygenic liability to mental disorders on COVID-19 outcomes in people with depression: the mediating role of anxiety.

ABSTRACT:

Background

Genetic vulnerability to mental disorders has been associated with coronavirus disease-19 (COVID-19) outcomes. We explored whether polygenic risk scores (PRSs) for several mental disorders predicted poorer clinical and psychological COVID-19 outcomes in people with pre-existing depression.

Methods

Data from three assessments of the Australian Genetics of Depression Study (N = 4405; 52.2 years ± 14.9; 76.2% females) were analyzed. Outcomes included COVID-19 clinical outcomes (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] infection and long COVID, noting the low incidence of COVID-19 cases in Australia at that time) and COVID-19 psychological outcomes (COVID-related stress and COVID-19 burnout). Predictors included PRS for depression, bipolar d

SUBMITTER: Monistrol-Mula A 

PROVIDER: S-EPMC11650167 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature