The effect of vitamin D supplementation on depression: a systematic review and dose-response meta-analysis of randomized controlled trials.

ABSTRACT: The impact of vitamin D supplementation on depressive symptoms remains uncertain. This study aimed to investigate the dose-dependent effects of vitamin D supplementation on depressive and anxiety symptoms in adults. We systematically searched PubMed, Scopus, and Web of Science up to December 2022 to identify randomized controlled trials evaluating the effects of vitamin D₃ supplementation on depression and anxiety symptoms in adults. Using a random-effects model, we calculated the standardized mean difference (SMD) for each 1000 IU/day vitamin D₃ supplementation. The GRADE tool assessed the certainty of evidence. Our analysis included 31 trials with 24189 participants. Each 1000 IU/day vitamin D₃ supplementation slightly reduced depressive symptoms in indiv

SUBMITTER: Ghaemi S 

PROVIDER: S-EPMC11650176 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature