Shared differential factors underlying individual spontaneous neural activity abnormalities in major depressive disorder.

ABSTRACT:

Background

In contemporary neuroimaging studies, it has been observed that patients with major depressive disorder (MDD) exhibit aberrant spontaneous neural activity, commonly quantified through the amplitude of low-frequency fluctuations (ALFF). However, the substantial individual heterogeneity among patients poses a challenge to reaching a unified conclusion.

Methods

To address this variability, our study adopts a novel framework to parse individualized ALFF abnormalities. We hypothesize that individualized ALFF abnormalities can be portrayed as a unique linear combination of shared differential factors. Our study involved two large multi-center datasets, comprising 2424 patients with MDD and 2183 healthy controls. In patients, individualized ALFF abnormalities were derive

SUBMITTER: Han S 

PROVIDER: S-EPMC11650188 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature