Functional gradient dysfunction in drug-naive first-episode schizophrenia and its correlation with specific transcriptional patterns and treatment predictions.

ABSTRACT:

Background

First-episode schizophrenia (FES) is a progressive psychiatric disorder influenced by genetics, environmental factors, and brain function. The functional gradient deficits of drug-naïve FES and its relationship to gene expression profiles and treatment outcomes are unknown.

Methods

In this study, we engaged a cohort of 116 FES and 100 healthy controls (HC), aged 7 to 30 years, including 15 FES over an 8-week antipsychotic medication regimen. Our examination focused on primary-to-transmodal alterations in voxel-based connection gradients in FES. Then, we employed network topology, Neurosynth, postmortem gene expression, and support vector regression to evaluate integration and segregation functions, meta-analytic cognitive terms, transcriptional patterns, and treat

SUBMITTER: Yao G 

PROVIDER: S-EPMC11650189 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature