Cognitive impairment in the schizophrenia spectrum: exploring the relationships of the g-factor with sociodemography, psychopathology, neurodevelopment, and genetics.

ABSTRACT:

Background

Cognitive impairment constitutes a prevailing issue in the schizophrenia spectrum, severely impacting patients' functional outcomes. A global cognitive score, sensitive to the stages of the spectrum, would benefit the exploration of potential factors involved in the cognitive decline.

Methods

First, we performed principal component analysis on cognitive scores from 768 individuals across the schizophrenia spectrum, including first-degree relatives of patients, individuals at ultra-high risk, who had a first-episode psychosis, and chronic schizophrenia patients, alongside 124 healthy controls. The analysis provided 10 g-factors as global cognitive scores, validated through correlations with intelligence quotient and assessed for their sensitivity to the stages on t

SUBMITTER: Yeh D 

PROVIDER: S-EPMC11650192 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature