Charting brain GABA and glutamate levels across psychiatric disorders by quantitative analysis of 121 ¹H-MRS studies.

ABSTRACT:

Background

Psychiatric diagnosis is based on categorical diagnostic classification, yet similarities in genetics and clinical features across disorders suggest that these classifications share commonalities in neurobiology, particularly regarding neurotransmitters. Glutamate (Glu) and gamma-aminobutyric acid (GABA), the brain's primary excitatory and inhibitory neurotransmitters, play critical roles in brain function and physiological processes.

Methods

We examined the levels of Glu, combined glutamate and glutamine (Glx), and GABA across psychiatric disorders by pooling data from 121 ¹H-MRS studies and further divided the sample based on Axis I disorders.

Results

Statistically significant differences in GABA levels were found in the combined psychiatric gr

SUBMITTER: Zhang J 

PROVIDER: S-EPMC11650199 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature