Advanced pentosan polysulfate sodium maculopathy with low cumulative exposure and hydroxychloroquine use.

ABSTRACT:

Purpose

To report a case of pentosan polysulfate sodium (PPS) maculopathy with cystoid macular edema (CME) with relatively low cumulative PPS exposure and a history of concurrent hydroxychloroquine use.

Observations

A 46-year-old female was treated with PPS daily for 10 years, and hydroxychloroquine intermittently over a span of five years, actively taking hydroxychloroquine for a sum of three years during PPS therapy. Despite a low risk for toxicity based on the cumulative exposure to either medication, fundoscopic examination and multimodal imaging revealed severe PPS maculopathy with CME two and a half years post-PPS cessation. CME was refractory to topical therapy and intravitreal anti-VEGF but improved with intravitreal dexamethasone. Bilateral improved visibility of th

SUBMITTER: Flester E 

PROVIDER: S-EPMC11650262 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature