CB2R activation enhances tumor-associated macrophages-mediated phagocytosis of glioma cell.

ABSTRACT:

Background

Cannabinoid administration has demonstrated promising anti-tumor effects for glioblastoma (GBM) by inhibiting glioma cell proliferation and inducing glioma cell death. However, the impact of cannabinoids and endocannabinoid receptors on immune cells within the tumor microenvironment (TME) remains largely unexplored. Tumor-associated macrophages (TAMs), the most abundant immune cells in the TME, and their mediated phagocytosis of tumor cells have shown potential in preclinical xenografts of various human malignancies. This study aimed to investigate the effect and mechanism of endocannabinoid receptor 2 (CB2R) on TAMs-mediated phagocytosis in xenografted mice with GL261-GFP cell lines.

Methods

We measured the phagocytic activity using immunofluorescence and flow cy

SUBMITTER: Lu S 

PROVIDER: S-EPMC11650289 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature