Monitoring concentration and lipid signature of plasma extracellular vesicles from HR⁺ metastatic breast cancer patients under CDK4/6 inhibitors treatment.

ABSTRACT: Extracellular vesicles (EVs) are cell-derived small membrane structures that transport various molecules. They have emerged as potential circulating biomarkers for monitoring responses to cancer therapies. This study aimed to comprehensively characterize plasma-carried EVs in hormone receptor-positive (HR⁺) metastatic breast cancer (MBC) patients treated with first-line CDK4/6 inhibitors (iCDK4/6) combined with endocrine therapy. MBC patients were classified into three groups based on their response to therapy: resistant, intermediate or sensitive. In a prospective cohort, we monitored the concentration of circulating EVs, analyzed their lipid signature and correlated these factors with treatment response. To facilitate the translation of EV research to clinical practice, we est

SUBMITTER: Richard M 

PROVIDER: S-EPMC11650302 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature