TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis.

ABSTRACT:

Objective

Steroidogenic factor-1 (SF1) neurons of the ventromedial hypothalamus play key roles in the regulation of food intake, body weight and glucose metabolism. The bile acid receptor Takeda G protein-coupled receptor 5 (TGR5) is expressed in the hypothalamus, where it determines some of the actions of bile acids on food intake and body weight through still poorly defined neuronal mechanisms. Here, we examined the role of TGR5 in SF1 neurons in the regulation of energy balance and glucose metabolism.

Methods

We used a genetic approach combined with metabolic phenotyping and molecular analyses to establish the effect of TGR5 deletion in SF1 neurons on meal pattern, body weight, body composition, energy expenditure and use of energy substrates as well as on possible change

SUBMITTER: Zizzari P 

PROVIDER: S-EPMC11650306 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature