Distinct clinical features of urothelial carcinoma with low-expressing human epidermal growth factor receptor 2 status.

ABSTRACT:

Background

Some urothelial carcinoma patients are ineligible for platinum-based chemotherapy, necessitating exploration of other effective therapeutic strategies. Human epidermal growth factor receptor 2 (HER2) protein overexpression, gene amplification or mutations exist in urothelial carcinoma. Our study is to investigate the correlation of three-tier assessment of HER2 expression with clinical pathological characteristics and prognosis of urothelial carcinoma.

Methods

HER2 expression in 75 urothelial carcinomas from Jiangsu Cancer Hospital was re-scored by immunohistochemistry and fluorescence in situ hybridization according to HER2 three-tier assessment standards. Its relationship with various pathological parameters of urothelial carcinoma and its correlation with progn

SUBMITTER: Huang X 

PROVIDER: S-EPMC11650335 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature