Using a two sample Mendelian randomization approach to explore the causal relationship between erectile dysfunction and lung function.

ABSTRACT:

Background

Recently, some observational studies have suggested potential associations between erectile dysfunction (ED) and respiratory function. However, the underlying biological mechanisms and causal relationships between ED and lung function require further investigation. This study aimed to explore the causalities between ED and lung function traits.

Methods

Single-nucleotide polymorphisms (SNPs) for ED were extracted from the Finngen_r7 (1,154 cases and 94,024 controls), and the summary statistics of respiratory function were extracted from the UK Biobank (UKB) (n=321,047). We utilized several Mendelian randomization (MR) methods to mitigate the impact of weak instrument bias and pleiotropy. To address potential confounding effects, multivariable MR (MVMR) analyses wer

SUBMITTER: Luo Y 

PROVIDER: S-EPMC11650337 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature