Unravelling the natural history of localised prostate cancer in the post-prostate specific antigen era: implications for clinical management.

ABSTRACT:

Background

Management of localised prostate cancer (PCa) remains controversial in the era of prostate-specific antigen (PSA) testing. This study aims to describe the natural history of men with PCa being followed up expectantly to evaluate disease mortality.

Methods

After exclusion, clinical data of 204 patients retrieved from a prospective large PCa registry were reviewed. Competing risk analysis were performed using the Fine-Gray model.

Results

The median age was 73 years old with a median follow up of 12.5 years. The median PSA was 8.85 ng/mL and the risk stratification were as follows: low (47.0%), intermediate (31.4%), and high risk (21.6%). There were 19 PCa (9.3%) and 84 non-PCa deaths (41.2%), with overall mortality at 50.5%. Multivariate analysis showed patie

SUBMITTER: Chin JLJ 

PROVIDER: S-EPMC11650342 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature