Identification of BIRC5 and HMMR as prognostic biomarkers for immune infiltration in prostate cancer.

ABSTRACT:

Background

Understanding the molecular mechanisms and identifying prognostic markers across various subtypes and stages of prostate cancer (PCa) are crucial for improving therapeutic strategies against the disease. This study focuses on discovering novel immune-related biomarkers that could aid in the evaluation and prognosis of PCa at different stages and serve as promising therapeutic targets.

Methods

Transcriptomic and clinical data from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases were analyzed to identify differentially expressed genes (DEGs) linked to PCa progression. The relationship between immune cell infiltration in the tumor microenvironment (TME) and the expression levels of baculoviral inhibitor of apoptosis protein repeat containin

SUBMITTER: Tang H 

PROVIDER: S-EPMC11650346 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature