Causal relationship between serum uric acid levels and male infertility: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

Uric acid is the final metabolic product of purines in the human body and has been implicated in the pathogenesis of various diseases. Nevertheless, the relationship between serum uric acid levels and male infertility remains inconclusive. This Mendelian randomization (MR) study aims to elucidate the potential impact of serum uric acid levels on the risk of male infertility.

Methods

We conducted the bidirectional MR analysis utilizing summary data from genome-wide association studies (GWAS) on serum uric acid levels and male infertility. The inverse variance weighted (IVW) method was employed to evaluate the primary outcomes, and multivariate MR analyses were conducted to combine estimates of the causal effects of multiple risk factors. Additionally, sensitivity a

SUBMITTER: Li Y 

PROVIDER: S-EPMC11650356 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature