Hierarchically Structured Biodegradable Microspheres Promote Therapeutic Angiogenesis.

ABSTRACT: Promoting neovascularization is a prerequisite for many tissue engineering applications and the treatment of cardiovascular disease. Delivery of a pro-angiogenic stimulus via acellular materials offers several benefits over biological therapies but has been hampered by interaction of the implanted material with the innate immune response. However, macrophages, a key component of the innate immune response, release a plurality of soluble factors that can be harnessed to stimulate neovascularization and restore blood flow to damaged tissue. This study investigates the ability of biodegradable poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres to restore tissue perfusion in a hind limb model of ischaemia. Microspheres exhibiting a hierarchical porous structure are associated with an increa

SUBMITTER: Hendow EK 

PROVIDER: S-EPMC11650400 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature