Herbal Amara extract induces gastric fundus relaxation via inhibition of the M2 muscarinic receptor.

ABSTRACT:

Background

Impaired gastric accommodation is one of the most frequent symptoms of functional dyspepsia. The safety and efficacy of conventional treatments remain to be proven and alternative herbal therapies have been proposed to alleviate gastrointestinal symptoms. This preclinical study examined the role of herbal Amara extract (containing Artemisia absinthium, Centaurium erythraea, Cichorium intybus, Gentiana lutea, Juniperus communis, Achillea millefolium, Peucedanum ostruthium, Salvia officinalis, and Taraxacum extracts) on gastric (fundus) accommodation and the possible implication of muscarinic receptors in its regulation.

Methods

The effect of Amara extract on fundus motility was investigated in organ baths of smooth muscle strips isolated from the fundus of guinea p

SUBMITTER: Pique-Borras MR 

PROVIDER: S-EPMC11650409 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature